The single D.332 Emeraude was first flown on 11 July 1933 by test pilot Marcel Doret. An all-metal single-spar cantilever low-wing monoplane; it was intended for service with Air Orient on its Paris-Saigon route. Power was provided by three 428.5kW Wright Cyclone radial engines and the aircraft had a trousered fixed landing gear. Several speed-with-load-over-distance world records fell to the D.332 in 1933 and it made many spectacular European flights. However it crashed on the final return stage of the inaugural Paris-Saigon service on 15 January 1935.

Three D.333s followed, each powered by 428.5kW Hispano-Suiza radial engines and accommodating ten passengers. One was lost in October 1937 while flying the Toulouse-Dakar service with Air France. The others flew in South America on the Buenos Aires-Natal route.

In 1936 the prototype of a new version appeared as the D.338. It was followed by 30 production examples for Air France. These had retractable landing gears, were powered by 484.5kW Hispano-Suiza V16/17 engines, and each accommodated up to 22 passengers. They were operated on the Paris-Cannes-Damascus-Hanoi and Paris-Dakar routes. Many continued to fly during World War II on government liaison and VIP duties and eight were used for a short time after the war.

The D.342 was a one-off development of the D.338, as was the D.620.