The F.XXII closely resembled the F.XXXVI but was somewhat smaller, accommodating 22 passengers. The prototype (PH-AJR) flew in early 1935 and was followed by two production machines. All three were delivered to KLM, the prototype in March and the other two in May 1935. One aircraft crashed on 14 July 1935, but the other two operated European routes until they were sold in the UK, PH-AJR becoming G-AFXR in August 1939 on joining British American Air Services, and PH-AJP being re-registered G-AFZP in the following month when it was acquired by Scottish Aviation. Impressed for RAF service as HM159 and HM160 in October 1941, the two aircraft were used for transport and crew training. HM159 caught fire in the air and was lost in the Highlands, but HM160 was returned to Scottish Aviation post-war under its previous civil registration. It flew between Prestwick and Belfast for a time before being grounded finally at the end of 1947.

A fourth F.XXII was built for Swedish AB Aerotransport and delivered in March 1935. Named Lappland, it flew a regular schedule between Malmo and Amsterdam until destroyed in an accident at Malmo in June 1936.